Submit Manuscript  

Article Details


CACNB2: An Emerging Pharmacological Target for Hypertension, Heart Failure, Arrhythmia and Mental Disorders

[ Vol. 8 , Issue. 1 ]

Author(s):

Nikolai M. Soldatov   Pages 32 - 42 ( 11 )

Abstract:


The voltage-gated Cav1.2 calcium channels respond to membrane depolarization by increasing the membrane permeability to Ca2+, a major signal for cardiac muscle contraction, regulation of vascular tone and CREB-dependent transcriptional activation. CACNB2 is one of the four homologous genes coding for the auxiliary Cavβ subunits, which are important modulators of the Ca2+ channel activity. Five serious mental disorders - autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia, - and three major cardiovascular diseases - hypertension, heart failure and sudden cardiac death, - have recently been linked to the CACNB2 gene coding for the Cavβ2 subunits. Here I will focus on the Cavβ2-specific molecular determinant β2-CED as an emerging pharmacological target.

Keywords:

Cav1.2 calcium channel, Cavβ subunits, CACNB2, heart failure, hypertension, mental disorders.

Affiliation:

Humgenex, Inc., Kensington, MD 20895, USA.

Graphical Abstract:



Read Full-Text article