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Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

[ Vol. 8 , Issue. 2 ]

Author(s):

Gaetano Santulli and Andrew R. Marks   Pages 206 - 222 ( 17 )

Abstract:


Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

Keywords:

Aging, arrhythmias, cognitive dysfunction, diabetes, excitation-contraction coupling, heart failure, IP3 receptors, metabolism, mitochondria, neurodegenerative disorders, RyR, skeletal muscle.

Affiliation:

The Wu Center for Molecular Cardiology, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, Department of Medicine, Columbia University, New York, NY, USA.

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