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Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

[ Vol. 8 , Issue. 2 ]


Gaetano Santulli and Andrew R. Marks   Pages 206 - 222 ( 17 )


Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.


Aging, arrhythmias, cognitive dysfunction, diabetes, excitation-contraction coupling, heart failure, IP3 receptors, metabolism, mitochondria, neurodegenerative disorders, RyR, skeletal muscle.


The Wu Center for Molecular Cardiology, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, Department of Medicine, Columbia University, New York, NY, USA.

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