Article Details


Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease

[ Vol. 10 , Issue. 3 ]

Author(s):

Sathish Kumar Natarajan, Karuna Rasineni, Murali Ganesan, Dan Feng, Benita L. McVicker, Mark A. McNiven, Natalia A. Osna, Justin L. Mott, Carol A. Casey and Kusum K. Kharbanda   Pages 237 - 248 ( 12 )

Abstract:


For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly and protein degradation. Here, we have explored the structural and functional changes that occur in hepatic and adipose tissue LDs following chronic ethanol consumption in relation to their role in the pathogenesis of alcoholic liver injury.

Keywords:

Liver, alcohol, steatosis, lipid, triglycerides, adipose, lipid droplet, perilipin, phosphatidylcholine, phosphatidylethanolamine, lipases, ATGL, HSL, TGH, lipolysis, lipophagy, VLDL, rab, dynamin, Src, HCV, MiRs, betaine.

Affiliation:

Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Veterans Affairs Nebraska Western Iowa Health Care System, Research Service (151), 4101 Woolworth Avenue, Omaha, Nebraska, 68105

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