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CRH Receptors in Human Reproduction

[ Vol. 11 , Issue. 1 ]

Author(s):

Antonis Makrigiannakis*, Thomas Vrekoussis, Emmanuel Zoumakis, Iordanis Navrozoglou and Sophia N. Kalantaridou   Pages 81 - 87 ( 7 )

Abstract:


Background: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system.

Objective: Herein, the role of CRH receptors in the female reproductive system is presented.

Results: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.

Conclusion: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.

Keywords:

CRH receptors, ovary, implantation, fetal immunotolerance, receptivity, parturition.

Affiliation:

Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, 1st Department of Pediatrics and Choremion Laboratory, Medical School, University of Athens, Athens, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, 2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Athens

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