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Recent Advances in Vaginal Delivery for the Treatment of Vulvovaginal Candidiasis

Author(s):

Sandeep Kaur and Sukhbir Kaur*   Pages 1 - 11 ( 11 )

Abstract:


Background: Vulvovaginal candidiasis (VVC) is a common vaginal infection caused by candida species, affecting 70% of the women. It may occur due to the imbalance in the vaginal micro-biodata, pregnancy, diabetes, use of antibiotics, frequent sexual activities or AIDS.

Aim: The main aim of this review is to provide overview about different vaginal delivery systems for the administration of antifungal agents like conventional, mucoadhesive and muco-penetrating delivery systems.

Method: The conventional delivery systems available are having limited efficacy due to the less residence time and adverse effects. In order to overcome these issues, delivery system with mucoadhesive and muco-penetrating properties is required. Mucoadhesive polymers are having excellent binding properties with mucin and thus increasing residence time. On the other hand, muco-penetrating polymers transport the antifungal agents across the mucus layer.

Results: This review summarizes the pathophysiology of VVC along with novel delivery systems for the treatment of infection through mucoadhesive and muco-penetrating approaches. Surface modifications of nano/ microparticles with mucoadhesive or muco-penetrating particles may results delivery systems with improved therapeutic efficacy.

Conclusion: Based on the available data conventional and mucoadhesive drug delivery systems have some limitations, still requires improvement/ development for safe and effective delivery of antifungal agents.

Keywords:

Valvovaginal candidiasis, Conventional delivery system, Mucoadhesion, Mucopenetration, Novel delivery systems, Candida albican.

Affiliation:

Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab)



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