Samreen Pervez, Muhammad Saeed, Haroon Khan* and Rukhsana Ghaffar Pages 746 - 752 ( 7 )
Background: Numerous therapeutic agents are in clinical practice for the treatment of inflammatory and painful conditions, but their applications have been challenged by various side /toxic effects. Therefore, new effective and safe therapies are most warrant, for which medicinal plant could be a significant alternative. Berberis baluchistanica has traditionally been used as analgesic and anti-inflammatory without any scientific background.
Objective: The current study was designed to evaluate the analgesic and anti-inflammatory like effects of extract B. baluchistanica in animal models.
Methods: For the study of antinociceptive effect, an extractof B. baluchistanica (100, 200 and 300 mg/kg i.p.), was tested in acetic acid-induced writhing and formalin tests. While for the anti-inflammatory action, carrageenan-induced paw edema, cotton pellet induced granuloma and xylene induced ear edema tests were used.
Results: The results showed the significant dose-dependent antinociceptive effect of extract of B. baluchistanica in acetic acid-induced writhing and formalin-induced flinching behavior tests. However, the effect was strongly antagonized by the injection of naloxone, suggesting the expression via opioidergic receptors. Similarly, strong anti-inflammatory action was illustrated in carrageenan- induced paw edema, cotton pellet induced granuloma and xylene induced ear edema tests and thus provided evidence for the versatile phytochemical nature of its phytochemical.
Conclusion: In short, it is concluded that the extract of B. baluchistanica exhibited significant antinociceptive and anti-inflammatory effects in animal models. Further detailed studies on the efficacy and safety as well as on the phytochemical investigation are required to ascertain its clinical uses.
Berberis Baluchistanica, crude extract, antinociceptive tests, anti-inflammatory tests, therapeutic potential, berberidaceae.
Department of Pharmacy, University of Peshawar, Peshawar, Department of Pharmacy, University of Peshawar, Peshawar, Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Department of Pharmacy, University of Malakand, Dir