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Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression

[ Vol. 14 , Issue. 3 ]

Author(s):

Saurabh Satija*, Harpreet Kaur, Murtaza M. Tambuwala, Prabal Sharma, Manish Vyas, Navneet Khurana, Neha Sharma, Hamid A. Bakshi, Nitin B. Charbe, Flavia C. Zacconi, Alaa A. Aljabali, Srinivas Nammi, Harish Dureja, Thakur G. Singh, Gaurav Gupta, Daljeet S. Dhanjal, Kamal Dua, Dinesh K. Chellappan* and Meenu Mehta*   Pages 321 - 332 ( 12 )

Abstract:


Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. HIF-1 has two subunits, HIF-1β (constitutive) and HIF-1α (inducible). The HIF-1α expression is largely regulated via various cytokines (through PI3K-ACT-mTOR signals), which involves the cascading of several growth factors and oncogenic cascades. These events lead to the loss of cellular tumor suppressant activity through changes in the level of oxygen via oxygen-dependent and oxygen-independent pathways. The significant and crucial role of HIF in cancer progression and its underlying mechanisms have gained much attention lately among the translational researchers in the fields of cancer and biological sciences, which have enabled them to correlate these mechanisms with various other disease modalities. In the present review, we have summarized the key findings related to the role of HIF in the progression of tumors.

Keywords:

Hypoxia, normoxia, microenvironment, tumor, HIF, hydroxylation, cancer progression.

Affiliation:

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Av. Vicuña McKenna 4860, 7820436 Macul, Santiago, Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Av. Vicuña McKenna 4860, 7820436 Macul, Santiago, Yarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, School of Science and Health, Western Sydney University, Penrith NSW 2751, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, School of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara-144411, Punjab, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW 2007, Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab



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